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phagesky

phagesky

by Rob Edwards Rob Edwards

Everything about phages, why they are cool, and how they dominate the microbes // Made at BlueskyFeeds.com

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  • 💙 Liked by 23 users
  • 📅 Updated 4 months ago
  • ⚙️ Provider graze.social

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Emmanuele Severi
@emmseveri.bsky.social
1 day ago
#microsky #phagesky Structural insights into non-tailed Vibrio #phages www.biorxiv.org/content/1….
Structure of NO16, a marine non-tailed vibriophage with a global distribution

www.biorxiv.org

Structure of NO16, a marine non-tailed vibriophage with a global distribution

Non-tailed phages remain an underexplored group in marine environments, as tailed phages have dominated sequence and culture collections. However, recent surveys indicate that non-tailed phages might ...
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Vivek Mutalik
@vivekmutalik.bsky.social
2 days ago
The Biology of Nucleus-Forming Jumbo Phages #phage #phagesky www.annualreviews.org/con….
The Biology of Nucleus-Forming Jumbo Phages

www.annualreviews.org

The Biology of Nucleus-Forming Jumbo Phages

Nucleus-forming jumbo bacteriophages display a surprisingly intricate replication cycle inside of bacterial host cells, challenging the long-standing paradigm of prokaryotic simplicity. The phage nucl...
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PLOS Biology
@plosbiology.org
2 days ago
Capsule diversity limits #phage host range by affecting receptor-binding protein (RBP) interactions in capsulated #bacteria. @pilardomingoc.bsky.social &co show that generalist phages evolve host range via RBP mutation & recombination, but specialists remain stable @plosbiology.org 🧪 plos.io/48nvOqY
Graphic representation of the recombination events in the Sugarlandvirus I and J variants. Top left: Representation of the variants isolates in the different strains in the three lines. Genome fragments of each parent are represented in a different color. Regions with the most abundant recombination events are marked and associated with a schematic representation of the functional annotation and intergenomic similarity between the two parental phages. Bottom left: 3D folding of the RBPγ. The consensus recombinant region, which is associated with the infection of the K-type 47, is represented in light orange. Variable positions detected in the protein sequence alignment of the variants are represented as hot pink spheres. The table indicates the percentage of identity of the parental protein sequences in three protein regions limited by the amino acids indicated. Right: Transmission electron microscopy (TEM) image of Klebsiella myoviruses artificially coloured, showing their characteristic contractile tails and icosahedral capsids. Image acquired by the Environmental and Biomedical Virology group (Institute for Integrative Systems Biology, Universitat de València-CSIC).
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Nonia Pariente
@npariente.bsky.social
2 days ago
How does the arms race between #bacterial defense systems and mobile genetic elements contribute to #microbiome community structure? Read below for an insightful exploration of this issue! It will not disappoint @plosbiology.org 🧪 #bacteria #immune #phage #ecology

The ecological roles of bacterial #immune systems are poorly understood. Rafael Custodio @ellinoralseth.bsky.social @brockhurstlab.bsky.social @brownlab.bsky.social & Edze Westra explore how mobile genetic elements and bacterial defenses shape #microbiome structure and function 🧪

plos.io
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PLOS Biology
@plosbiology.org
2 days ago
Capsule diversity limits #phage host range by affecting receptor-binding protein (RBP) interactions in capsulated #bacteria. @pilardomingoc.bsky.social &co show that generalist phages evolve host range via RBP mutation & recombination, but specialists remain stable @plosbiology.org 🧪 plos.io/48nvOqY
Graphic representation of the recombination events in the Sugarlandvirus I and J variants. Top left: Representation of the variants isolates in the different strains in the three lines. Genome fragments of each parent are represented in a different color. Regions with the most abundant recombination events are marked and associated with a schematic representation of the functional annotation and intergenomic similarity between the two parental phages. Bottom left: 3D folding of the RBPγ. The consensus recombinant region, which is associated with the infection of the K-type 47, is represented in light orange. Variable positions detected in the protein sequence alignment of the variants are represented as hot pink spheres. The table indicates the percentage of identity of the parental protein sequences in three protein regions limited by the amino acids indicated. Right: Transmission electron microscopy (TEM) image of Klebsiella myoviruses artificially coloured, showing their characteristic contractile tails and icosahedral capsids. Image acquired by the Environmental and Biomedical Virology group (Institute for Integrative Systems Biology, Universitat de València-CSIC).
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Freya Harrison
@friendlymicrobe.bsky.social
2 days ago
Now at @bsacandjac.bsky.social #AntibioticResistance & Mechanisms: @reepkpd333.bsky.social is telling us how her hospital PK/PD lab is exploring suitable models to evaluate #phage + abx combinations scholar.google.com/citati…. #MicroSky
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PLOS Biology
@plosbiology.org
3 days ago
Capsule diversity limits #phage host range by affecting receptor-binding protein (RBP) interactions in capsulated #bacteria. @pilardomingoc.bsky.social &co show that generalist phages evolve host range via RBP mutation & recombination, but specialists remain stable @plosbiology.org 🧪 plos.io/48nvOqY
Graphic representation of the recombination events in the Sugarlandvirus I and J variants. Top left: Representation of the variants isolates in the different strains in the three lines. Genome fragments of each parent are represented in a different color. Regions with the most abundant recombination events are marked and associated with a schematic representation of the functional annotation and intergenomic similarity between the two parental phages. Bottom left: 3D folding of the RBPγ. The consensus recombinant region, which is associated with the infection of the K-type 47, is represented in light orange. Variable positions detected in the protein sequence alignment of the variants are represented as hot pink spheres. The table indicates the percentage of identity of the parental protein sequences in three protein regions limited by the amino acids indicated. Right: Transmission electron microscopy (TEM) image of Klebsiella myoviruses artificially coloured, showing their characteristic contractile tails and icosahedral capsids. Image acquired by the Environmental and Biomedical Virology group (Institute for Integrative Systems Biology, Universitat de València-CSIC).
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Vivek Mutalik
@vivekmutalik.bsky.social
3 days ago
#phage #phagesky

The host range of generalist and specialist phages in capsule-diverse Klebsiella hosts is driven by the evolvability of receptor-binding proteins @plosbiology.org from @pilardomingoc.bsky.social journals.plos.org/plosbiology/...

journals.plos.org
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Emmanuele Severi
@emmseveri.bsky.social
3 days ago
#microsky #phagesky #phage in the gut www.nature.com/articles/s41...
Long-read metagenomics reveals phage dynamics in the human gut microbiome - Nature

www.nature.com

Long-read metagenomics reveals phage dynamics in the human gut microbiome - Nature

Complex prophage integration dynamics, including low-level induction, cross-family host range and transposase-mediated mobilization, challenge existing paradigms and deepen our understanding of phage–...
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Emmanuele Severi
@emmseveri.bsky.social
4 days ago
#microsky #phagesky #phage #virus academic.oup.com/nar/adva….
Virus taxonomy: the database of the International Committee on Taxonomy of Viruses

academic.oup.com

Virus taxonomy: the database of the International Committee on Taxonomy of Viruses

Abstract. Taxonomic classification underlies all biological science and is the basis for comparative analysis of biological organisms and therefore our und
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Rob Edwards
@linsalrob.bsky.social
4 days ago
Long read Metagenomics, #phage and #prophage in the gut by Ami Bhatt's group. Beautiful data showing changes in phages over two years #phagesky www.nature.com/articles/s41...
Long-read metagenomics reveals phage dynamics in the human gut microbiome - Nature

www.nature.com

Long-read metagenomics reveals phage dynamics in the human gut microbiome - Nature

Complex prophage integration dynamics, including low-level induction, cross-family host range and transposase-mediated mobilization, challenge existing paradigms and deepen our understanding of phage–...
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Lab bunny 🦠🇨🇴
@bohorquezalejo.bsky.social
4 days ago
My boss is in a new documentary!!! You should check it out because, I don't know if you've heard but phages are pretty cool 😎😎 #phagesky

THIS WAS GREAT FUN!! The team was watching last night and we really enjoyed getting to be a part of it Thanks to the production team for highlighting the BBH lab work, among other @pasteur.fr groups If you missed it last night, no worries, you can check it out here www.france.tv/documentaire...

www.france.tv
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Jacques Dainat
@jacquesdainat.bsky.social
5 days ago
Glad to have contributed to this study describing a novel Tequintavirus infecting Salmonella enterica serotype Tennessee. My first involvement in bacteriophage research! #phages #bacteriophage link.springer.com/article….
Characterization and comparative genome analysis of a new Tequintavirus isolated on Salmonella enterica serotype Tennessee - BMC Research Notes

link.springer.com

Characterization and comparative genome analysis of a new Tequintavirus isolated on Salmonella enterica serotype Tennessee - BMC Research Notes

Objective The rise in multidrug-resistant pathogenic bacteria presents a major current challenge, highlighting the urgent need for alternatives and sustainable biocontrol strategies. We aimed to isola...
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cob
@cobrate.mastodon.social.ap.brid.gy
5 days ago
#NOW sur #France5 : voir le positif #sante #espoir #science
Traquer l'invisible : Nos chercheurs face à la menace mondiale des virus et des bactéries Documentaire scientifique (France, 2025) • 1h05 Marina Carrère d'Encausse rencontre des chercheurs qui traquent virus et bactéries partout dans le monde et décrypte les découvertes les plus porteuses d'espoir.
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Microbes.Info
@microbesinfo.bsky.social
5 days ago
New collection of #bacteria-eating #viruses to tackle #hospital #superbug ... | #phage | #virus | #wastewater | #bacteriophage | #antibiotics | By @unisouthampton.bsky.social via @sciencex.bsky.social
New collection of bacteria-eating viruses to tackle hospital superbug

phys.org

New collection of bacteria-eating viruses to tackle hospital superbug

Potential treatments for one of the world's most dangerous hospital superbugs have been found in a surprising location—hospital toilets.
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Rita Ramalhete
@ritaramalhete.bsky.social
5 days ago
Latest in our #Phage collection Through #experimentalevolution, researchers at @ucsandiego.bsky.social trained #phages to increase their ability to inhibit multidrug-resistant and extensively drug-resistant Klebsiella pneumoniae 🧫 @natcomms.nature.com www.nature.com/articles/s41...
Experimental phage evolution results in expanded host ranges against antibiotic resistant Klebsiella pneumoniae isolates - Nature Communications

www.nature.com

Experimental phage evolution results in expanded host ranges against antibiotic resistant Klebsiella pneumoniae isolates - Nature Communications

Ghatbale et al. adapted a co-evolutionary technique to develop Klebsiella pneumoniae phages to be highly active longitudinally against K. pneumoniae clinical isolates, including drug resistant isolate...
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Emmanuele Severi
@emmseveri.bsky.social
6 days ago
#microsky #phagesky Transposon mutagenesis of jumbo #phage using an anti-CRISPR factor as selectable marker www.biorxiv.org/content/1….
Bacteriophage genome-wide transposon mutagenesis

www.biorxiv.org

Bacteriophage genome-wide transposon mutagenesis

Bacteriophages have genomes that span a wide size range, are densely packed with coding sequences, and frequently encode genes of unknown function. Classical forward genetics has defined essential gen...
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Emmanuele Severi
@emmseveri.bsky.social
6 days ago
#microsky #phagesky More on how Arbitrium regulates temperate #phage lifestyle in Bacillus www.biorxiv.org/content/1….
Arbitrium systems control lysis/lysogeny through the regulation of small antirepressor proteins

www.biorxiv.org

Arbitrium systems control lysis/lysogeny through the regulation of small antirepressor proteins

Many temperate Bacillus phages utilize the arbitrium signaling system to control lysis/lysogeny decisions. While the function of the arbitrium signal AimP and its receptor AimR are well known, it is u...
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Nicolas Fanget
@nfanget.bsky.social
6 days ago
Everyone interested in #virus loves a #bacteriophage right? It's amazing they are the most abundant and diverse biological entity on the planet, yet were discovered just over 100 years ago! To give them the attention we believe they deserve, npj Viruses has launched three collections on #phages:
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Emmanuele Severi
@emmseveri.bsky.social
7 days ago
#microsky #phagesky #phage Anyone who’s tried deleting prophages in the lab by HR knows the difficulties of the task. Here we have an example of how HR-mediated natural transformation might hit the same hurdle in a more native context. academic.oup.com/mbe/arti….
Chromosomal Curing Drives an Arms Race Between Bacterial Transformation and Prophage

academic.oup.com

Chromosomal Curing Drives an Arms Race Between Bacterial Transformation and Prophage

Abstract. Transformation occurs when bacteria import exogenous DNA via the competence machinery and integrate it into their genome through homologous recom
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Patrick Kenney, MD MS
@patrickkenney.bsky.social
8 days ago
I started studying phages just over 4 years ago. The project that started it all is finally published. We isolated 6 closely related anti-Acinetobacter phages and showed that they are not capsule-specific and can reduce bacterial load in a rat model. More work still to come on this! #phagesky #IDsky
A bacteriophage genus infects carbapenem resistant Acinetobacter baumannii via a non-capsular receptor and provides protection in vivo

www.cell.com

A bacteriophage genus infects carbapenem resistant Acinetobacter baumannii via a non-capsular receptor and provides protection in vivo

Microbiology; Virology
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Vivek Mutalik
@vivekmutalik.bsky.social
9 days ago
#phagesky #phage

Bacteriophage density influences the rate of resistance evolution. DOI: 10.1101/2025.10.05.680490 https://pubmed.ncbi.nlm.nih.gov/41256655/

pubmed.ncbi.nlm.nih.gov
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