phagesky

pubmed.ncbi.nlm.nih.gov

Multiple prophage acquisition events over the course of an outbreak drive lysogenic conversion of capsular polysaccharides produced by carbapenem-resistant Acinetobacter baumannii isolates - PubMed

Prophages are important drivers of bacterial evolution and can provide pathogens with additional factors that enhance virulence and/or resistance properties. However, they are not considered when assessing the dynamics of outbreak populations using phylogenetic approaches. Recently, we showed that B …

www.healio.com

Engineered phages treat rare condition in transplant recipient

A kidney transplant recipient with progressive malakoplakia triggered by multidrug-resistant Escherichia coli was successfully treated with a first-in-human engineered bacteriophage cocktail, researchers reported.Bacteriophages — or phages — are viruses that target and consume bacteria. They have shown promise in recent years as a nontraditional alternative to antibiotics for patients with

www.nature.com

Pervasive phosphorylation by phage T7 kinase disarms bacterial defences - Nature

The T7 bacteriophage deactivates bacterial defence systems through T7K phosphorylation of nearly all host and phage proteins during infection.

www.nature.com

Pervasive phosphorylation by phage T7 kinase disarms bacterial defences - Nature

The T7 bacteriophage deactivates bacterial defence systems through T7K phosphorylation of nearly all host and phage proteins during infection.

medicalxpress.com

Scientists have designed a functioning virus from scratch using AI. What you need to know

Artificial intelligence has designed viruses that can infect bacteria and reproduce—a first that shows AI is beginning to do more than analyze the genetic code of living things. It can write new…

github.com

GitHub - Vini2/phables: 🫧🧬 From fragmented assemblies to high-quality bacteriophage genomes

🫧🧬 From fragmented assemblies to high-quality bacteriophage genomes - Vini2/phables

www.nature.com

Phage-encoded contingency loci enable bet-hedging against host defence mechanisms - Nature Microbiology

Diverse E. coli phage genomes have hypermutable DNA regions that promote reversible frameshift mutations through DNA polymerase slippage, generating population heterogeneity that enables host exploita...

www.biorxiv.org

Viruses, Proviruses and Satellites from Asgard Archaea Enrichments Reveal Complex Microbial Interactions

Asgard archaea are the closest known relatives of eukaryotes and are central to models of eukaryogenesis involving archaeal bacterial symbiosis, yet the contribution of viruses remains unexplored. Her...

pubmed.ncbi.nlm.nih.gov

Structural and enzymatic insights into QatD, a dual-function TatD-like nuclease in the QatABCD anti-phage defense system - PubMed

The qatABCD system is a widespread anti-phage module featuring a core QatBC complex, but the specific biological role of its conserved component, QatD, has long been enigmatic. Here, we establish QatD is a TatD-family nuclease co-opted for antiviral defense. The crystal structure of Acinetobacter ba …

journals.asm.org

Dental wastewater reveals a hidden reservoir of oral bacteriophage diversity | Microbiology Spectrum

The human oral cavity contains a diverse microbial community, but the bacteriophages (phages) that infect many oral bacteria remain poorly characterized. This gap limits our understanding of how phage...

pharmaphorum.com

SNIPR phage therapy clears MDR infection in first patient

A kidney transplant patient with a resistant infection is the first to be treated using a bacteriophage therapy developed by Denmark's SNIPR Biome.

journals.plos.org

Intact architectures of myophage phi92 in extended and contracted states

Author summary With the increasing severity of the problem of drug-resistant bacteria, phage therapy is regaining renewed attention as an effective alternative strategy. Myophage phi92 exhibits broad-...

www.theguardian.com

Safety fears as scientists make first viruses designed by AI

Researchers say breakthrough offers hope for new medicines but also raises urgent biosecurity questions