1. Bluesky Feeds /
  2. Kate Michie /
  3. Protein Cosmos

Feed for scientists interested in all aspects of Protein Science- think structural biology, biophysics, mass spec. (follows posts with cryoEM structural biology, alphafold, biophysics). tag with 🧬🧶

Feed on Bluesky

Feeds Stats

  • 💙 Liked by 93users
  • 📅 Updated 10 months ago
  • ⚙️ Provider bluefacts.app

Protein Cosmos Likes over time

Like count prediction
The feed Protein Cosmos has not gained any likes in the last month.

Feed Preview for Protein Cosmos

Oli Clarke
@olibclarke.bsky.social
about 2 hours ago
@emdatabank.bsky.social EMPIAR entry for stomatin complex from @fravallese.bsky.social and myself released - I hope it will be useful for folks studying #cryoem compositional heterogeneity in pseudo/mixed symmetry systems, as classifying out AQP1 and UT-B was quite a challenge for us at least!

www.ebi.ac.uk

EMPIAR-13732 Stomatin encapsulates aquaporin-1 and urea transporter-B in the erythrocyte membrane

EMPIAR, the Electron Microscopy Public Image Archive centered at EMBL-EBI, is a public resource for raw electron microscopy images related to EMDB, contains micrographs, particle sets and tilt-ser...

1
1
4
cryoEM papers
@cryoempapers.bsky.social
about 2 hours ago
Cryo-EM of amyloid fibrils: Advances, challenges, and translational applications pubmed.ncbi.nlm.nih.gov/4… #cryoEM
0
1
1
Zoe McElligott
@nanopharmnc.bsky.social
about 2 hours ago
I think this is the thing that the general public doesn't get. Thanks for stating
AI fails when there is no reliable training and validation data...so yes, we use AI-eque approaches all the time -- for structural biology and the initial phases of drug discovery they really speed things up. Once you open up the biology hood, though, things become complicated quickly.
0
0
2
@smahtnetwrk.bsky.social
about 3 hours ago
Introducing D&D-seq, a single-cell technology for mapping DNA-protein interactions with improved sensitivity. Compatible with multi-omics workflows, the method offers new opportunities to study gene regulation in health and disease. Learn more: news.weill.cornell.edu/ne….

news.weill.cornell.edu

A Breakthrough Single-Cell Method for Mapping DNA-Protein Interactions

A new technology allows scientists to map, in single cells, the DNA binding sites of transcription factors and other regulatory proteins that control gene activity, according to a study led by investi...

0
0
0
Emily M. Bender
@emilymbender.bsky.social
about 3 hours ago
The author seems to have equated "AI" with LLMs, and then used them as synonyms. But neither AlphaFold nor GNoME are language models! So even while moving away from the imprecision of "AI" this author has not succeeded in writing more clearly. >>
Screencap from linked article:
"Recently, the ability of large language models (LLMs) to predict protein structures and to accelerate the discovery of new materials has revolutionized both fields. New AI agents can now carry out many aspects of research design and analysis. But there is a"
2
5
15
cryoEM papers
@cryoempapers.bsky.social
about 3 hours ago
Computational approaches for protein complex modeling for intermediate resolution cryo-EM maps pubmed.ncbi.nlm.nih.gov/4… #cryoEM
0
1
1
Dr. Christine Beavers
@xtalgrrl.bsky.social
about 4 hours ago
The CSHL Macromolecular Crystallography school, well know and respected, has extended the deadline. They offer lots of support for student travel and attendance. Apply here: meetings.cshl.edu/courses…. #chemsky
Macromolecular Crystallography

meetings.cshl.edu

Macromolecular Crystallography

Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

0
0
1
cryoEM papers
@cryoempapers.bsky.social
about 4 hours ago
Calcium-sensing receptor involved in the oral perception of kokumi substances pubmed.ncbi.nlm.nih.gov/4… #cryoEM
0
0
0
TotiMOL
@totimol.bsky.social
about 5 hours ago
Nature's nucleases evolved for a microbe - not your crop or your therapy. EvoForge redesigns RNA-guided nucleases with inverse folding + evolutionary constraints: bold where the fold allows, careful where catalysis demands. Beat the wild type. Prove it by cryo-EM. #CRISPR
0
0
1
Chenxin Li, PhD
@chenxinli2.bsky.social
about 5 hours ago
Viewing protein structures really tickles the data visualization part of my brain. Doing this as part of prepping for my bioinformatics class. Decided to put in a lecture on structures. This is entry 102M from PDB, sperm whale myoglobin as an example. More detail in alt text.
Polypeptide chain colored in pink against white background. The structure is mostly alpha helices with some loops. Heme is colored blue. A sulfate is colored yellow and red. His93, which coordinates the heme, is colored orange.
2
0
6
cryoEM papers
@cryoempapers.bsky.social
about 5 hours ago
Insights into the structure and diversity of the bacterial flagellum from cryo-EM studies pubmed.ncbi.nlm.nih.gov/4… #cryoEM
0
0
0
Abyssal Doomrock
@deathbymeteor.bsky.social
about 5 hours ago
Cool, you just banned a bunch of tools for building better vaccines and medical treatments because LLMs are used to understand molecular and protein structures. Hurray, you set back medical science!
0
0
1
Iris van Rooij 💭
@irisvanrooij.bsky.social
about 5 hours ago
This editor/author does the same “trick” as he writes: "Recently, the ability of large language models (LLMs) to predict protein structures and to accelerate the discovery of new materials has revolutionized both fields. New AI agents can now carry out many aspects of research design and analysis.”
AI in scientific publishing: Slower, worse, and more expensive

www.science.org

AI in scientific publishing: Slower, worse, and more expensive

There’s a saying in the management world, popularized by NASA administrator Daniel Goldin in the 1990s, that the goal of technological improvements is to make products faster, better, and cheaper. Alt...

2
1
6
National Academy of Sciences
@nasonline.org
about 6 hours ago
The 2027 NAS Award for Scientific Discovery will recognize a significant accomplishment in basic research in #biochemistry, #biophysics, or #chemistry. Help us honor an outstanding scientist by submitting a nomination today! www.nasonline.org/award/n…. #NASaward
0
0
0
cryoEM papers
@cryoempapers.bsky.social
about 6 hours ago
Recent cryo-EM structures redefine the functional amyloid landscape pubmed.ncbi.nlm.nih.gov/4… #cryoEM
0
0
0
Cameron Thrash
@jcamthrash.bsky.social
about 7 hours ago
AlphaGEM enables precise genome-scale metabolic modelling by integrating protein structure alignment with deep-learning-based dark metabolism mining www.nature.com/articles/s41... #jcampubs
0
0
3
Eterna
@eternagame.org
about 7 hours ago
Eternacon 12 will be Sunday, July 26, 9am to 2pm PT featuring talks on player pseudoknot design techniques, the Montparnasse algorithm solving the Eterna100, an RNA scaffold for cryo-EM, and results for our pilot Replicase puzzle. #RNAsky Free to register at eternagame.org/eternacon/2026
Logo for eternacon 12
0
2
2
cryoEM papers
@cryoempapers.bsky.social
about 8 hours ago
GoToCloud: Development and future of the cloud-based platform for cryo-EM structure-based drug DesignDevelopment and future of GoToCloud pubmed.ncbi.nlm.nih.gov/4… #cryoEM
0
0
1
paddington bear hate account
@jamesacetate.bsky.social
about 8 hours ago
I think UCL/Birkbeck/Imperial/KCL always had a strong structural biology pedigree (Rosalind Franklin was at KCL/Birkbeck) and bio AI is kind of an extension of structural biology Bio AI as predates a lot of gen AI people are familiar with by decades
1
0
1
cryoEM papers
@cryoempapers.bsky.social
about 9 hours ago
Pursuing the physics of cryo-EM image formation pubmed.ncbi.nlm.nih.gov/4… #cryoEM
0
1
5
Kelvin Lau @klausenhauser on 🙅‍♂️🐘🪡
@klausenhauser.bsky.social
about 9 hours ago
There are usually not reports or mentions during the protein design process that it does not match the original design or the oracle that filters it. What does that mean? Anyone have a word for that? Im sure some of you can appreciate that the model and data differ by -1 positions
1
0
2