Kate Michie 
www.science.org
The knotty problem of RNA structure prediction
Artificial intelligence enables the design of RNA pseudoknots
Feed for scientists interested in all aspects of Protein Science- think structural biology, biophysics, mass spec. (follows posts with cryoEM structural biology, alphafold, biophysics). tag with đ§Źđ§¶
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Man I miss when we were sourcing idle playstations to research novel protein interactions.
Lets go back to that.
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Jeff Lengyel & TEM Team at Thermo Fisher Scientific
@jefflengyeltemteam.bsky.social
about 6 hours ago Explore this compelling video featuring @shahmora.bsky.social and her teamâs work on neurodegenerative disease. Powered by the Krios Cryo-TEM, #cryoEM and #cryoET are helping visualize cellular and molecular changes and uncover some of the earliest events in neurodegeneration. lnkd.in/p/gGZupgQz
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đŹ Biophysics Workshop 2026
12â13 nov | ICF-UNAM
Explora cĂłmo convergen FĂsica, BiologĂa y QuĂmica a travĂ©s de tĂ©cnicas avanzadas y aplicaciones en sistemas biofĂsicos.
âš Conferencias + prĂĄcticas
đ Dirigido a: Licenciatura y posgrado
đ Evento gratuito
#BiofĂsica #ICF #UNAM
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Major spliceosomal RNA secondary structures, interactions (PDB), evolutionary conservation (PhyloP & Rfam SEEDs), and disease associations (DâSouza et al 2026). All in one monstrously busy plot. đ
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A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature... Read more
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Did you know the protein structures are DIFFERENT in a scrambled egg vs an egg with intact yolk? Yeah. Wtf is THAT about, EGG?!
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5/5 Big shout-out to Asantewaa Jones for being a fantastic undergraduate research assistant to Leanna and Dharma đŹ, and to our long-time collaborator Sylvie Ricard-Blum for sharing with us her expertise on ECM protein-protein interactions âïž!
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@annadragos.bsky.social
about 11 hours ago Check out our new preprint: chemically switching off SpbK â an anti-phage immune system in B. subtilis â lets the tamed phage SPÎČ break free again đŠ đ§Ș. Collab with JP Gerdt's chem lab (Indiana) and structural biology teams at Monash & Griffith.
doi.org/10.64898/202...
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I am looking for an academic position. I would love to have colleagues that are supportive and interested in membrane biophysics. Wish me luck đ
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Engineering inflammation-responsive proteins through nitric oxide-caged amino acids
->Nature | More on "Nitric oxide responsive protein engineering" at BigEarthData.ai
www.nature.com
Engineering inflammation-responsive proteins through nitric oxide-caged amino acids
a, Reaction schematic of the NO-decaging progress of NO-responsive glutamate. Glutamate was Fmoc-derivatized to enhance absorption at A280. bâd, Evaluating the decaging reaction yield of Fmoc-1 (b), Fmoc-2 (c), Fmoc-3 (d) with 1 equivalent (eq) or 4 eq of DEA NONOate in PBS. The absorption (A280) of generated Fmoc-Glutamate and benzotriazoles were detected at the endpoint by HPLC-UV with a 5â95% gradient of methanol in H2O. The methoxy-substituted OPA-caged glutamate exhibited the highest reaction efficiency, with approximately 95% conversion (n = 3 independent experiments) when treated with 4 eq DEA NONOate. e, Reaction schematic of the NO-decaging progress of NO-responsive Aspartic acid. fâh, Evaluating the decaging reaction yield of 4 (f), 5 (g), 6 (h) with 2 eq of DEA NONOate in PBS. The absorption (A280) of generated benzotriazoles were detected at the endpoint by HPLC-UV with a 5â95 % gradient of methanol in H2O. The methoxy-substituted OPA-caged aspartic acid exhibited the highest reaction efficiency, with approximately 80% conversion when treated with 2 eq DEA NONOate. Experiments in bâd and fâh were repeated independently three times with similar results. Source data a, Enrichment of bacterial cells expressing active and specific NorERS using FACS screening. The gated R + /Râ populations...
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@robsport.bsky.social
about 12 hours ago I read Watson's book. There was a race for the DNA structure. Pauling was involved. Watson got in Franklin's desk when she was away (I think with Wilkins permission) and saw the helical x-ray picture of DNA. He knew immediatley it was helical. Crick worked out the structure with energy calculations.
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Agentic AI is changing how research is done. AI scientists can read papers, propose hypotheses, call models, and determine which experiments to prioritize next....
đ developer.nvidia.com/blogâŠ
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đŁ I am super thrilled to announce that during âEmerging Science Weekâ the MSAF subgroup of the Biophysical Society will run a webinar with three awesome speakers on âLipids Feeling the World.â More info, including how you sign up, is contained in the ALT text of the image!
Please share widely! đ§Ș
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To make these hidden phenomena measurable, weâll take a "build it if it doesnât exist" approach: multiscale microscopy, high-throughput force manipulation and molecular biophysics tools. Weâll bring experiments, theory and computation together across biophysics, engineering and ocean science. 5/8
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How to make cheap but still functional plant ribosome proteins? Our new preprint explores this question in broomrapes, legumes, geraniums, and Silene. We did some cool protein structure modeling as well. www.biorxiv.org/content/1âŠ.
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Structural biologists study the mechanisms that underpin damage to and repair of the genome, the way that these genetic changes lead to cancer, and ways for us to use this knowledge to discover and develop new treatments to fight cancer. More at PDB-101:
pdb101.rcsb.org
PDB101: Learn: Exploring the Structural Biology of Cancer
Cells capture and utilize many forms of energy to power their molecular processe
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I got a Pfizer booster about a month ago from my City Health Department, not knowing whether or not I would continue to be able to get them. My preference is the protein subunit based Novavax/Nuvaxovid/Sanofi, because, (according to some of the reports I've read) it has longer lasting effect.
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IMO the field suffers with nomenclature. No connection is made between highly homologous proteins because most scientists are lay in the area of protein structure. So thereâs a general (willful) ignorance of due diligence. But as others (maybe Phil) have pointed out thereâs always AI. ;)
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Integrative Biophysics of Membranes @CBS Montpellier
@membranesbiophy.bsky.social
about 19 hours ago A new review from our team in Current Opinion in Structural Biology
Recent advances on structure and dynamics of G proteinâcoupled receptors using single-molecule Förster resonance energy transfer
Emmanuel Margeat @emmanuelmargeat.bsky.social
Check out our latest opinion on #smFRET to study #GPCR with Robert Quast @rbquast.bsky.social. We summarize recent findings, methodological advancements and talk about challenges and limitations to translate FRET into structural dynamics information #openaccess www.sciencedirect.com/science/arti...
www.sciencedirect.com
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Last call: registration for the 9th Austrian Cryo-EM (ACE) Symposium closes tomorrow, 1 September.
24-25 Sept at the IMP, Vienna BioCenter. Eight invited speakers, selected talks, poster session.
events.vbc.ac.at/imp_evenâŠ.
#cryoEM #cryoET
events.vbc.ac.at
Cryo-EM Symposium 2026
Register here for the Cryo-EM Symposium 2026, 24-25 September at the IMP, Campus-Vienna-Biocenter 1, 1030 Vienna.Please select the applicable registration fee and add it to the cart. Please click on t...
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đŠ Structural biology of retron-mediated immunity against phages
How do bacteria defend themselves against phages? This review shows how retrons produce msDNA, which helps detect phage infection and activate bacterial immune responses.
By Monika JasnauskaitÄ & @patrick-pausch.bsky.social 2/3
doi.org
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