Kate Michie 
inari.com
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Inari is the SEEDesign™ company, using new breeding technology to design seeds for a more sustainable global food system.
Feed for scientists interested in all aspects of Protein Science- think structural biology, biophysics, mass spec. (follows posts with cryoEM structural biology, alphafold, biophysics). tag with 🧬🧶
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Nanoscale 3D Anatomy of the Western Flower Thrips Reproductive System Revealed by Volume Electron Microscopy: Extreme Miniaturization and Evolutionary Adaptations for Pest Fecundity pubmed.ncbi.nlm.nih.gov/4… #cryoEM
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A robust workflow for 3D imaging of human mitochondria using cryo-electron tomography www.biorxiv.org/content/1… #cryoEM
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Redox-Triggered Coupling Network Mediates Long-Range Energy Trans-duction in Respiratory Complex I www.biorxiv.org/content/1… #cryoEM
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I remember when we had to make do with roast chicken models of membrane protein complexes.
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How do you envision the integration of AI-driven approaches in protein engineering transforming traditional biochemistry methods, especially in terms of efficiency and innovation?
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Integrating glycosylation in de novo protein design with ReGlyco Binder Design Filter www.biorxiv.org/content/1… #cryoEM
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The authors included RRIDs in their in Biochemistry and Biophysics Reports paper! We value the author's support of reproducibility. #RRID #methodsmatter #ReproducibleResearch
doi.org
The binding property of a monoclonal antibody against the extracellular domains of aquaporin-4 directs aquaporin-4 toward endocytosis
Read the full paper: The binding property of a monoclonal antibody against the extracellular domains of aquaporin-4 directs aquaporin-4 toward endocytosis
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RRIDs were included in this in Cell Biochemistry and Biophysics paper. We value the author's support of reproducibility. #RRID #methodsmatter #reproducibility
doi.org
In Vitro Ocular Cytotoxicity of BEE Venom in ARPE-19, NTM5, HCET, and HCEC-12 Cell Lines - Cell Biochemistry and Biophysics
Read the full paper: In Vitro Ocular Cytotoxicity of BEE Venom in ARPE-19, NTM5, HCET, and HCEC-12 Cell Lines
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I am now looking for opportunities in area of synthetic biology and metabolic engineering of bacterial systems to address environmental challenges and contribute to sustainability goals.
Please feel free to connect or recommend relevant opportunities.
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Ionic disorder and oligomerization could shift protein redox states — but without direct photon measurements, this is a solid biophysics story, not a biophoton one.
bioRxiv Biophysics@biorxiv-biophys.bsky.social
Ionic strength modulates structural disorder and protein oligomerization in the marginally disordered Phd transcription factor https://www.biorxiv.org/content/10.64898/2026.04.15.718675v1
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5. Protein language models improve thermostability
Combining multiple mutations guided by language models enhances enzyme stability, demonstrating the power of AI-assisted protein engineering.
🔗 onlinelibrary.wiley.com/d….
onlinelibrary.wiley.com
Optimizing enzyme thermostability by combining multiple mutations using protein language model
Optimizing enzyme thermostability is essential for advancements in protein science and industrial applications. Currently, (semi-)rational design and random mutagenesis methods can accurately identif...
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4. Protein engineering in the deep learning era
Explores how AI transforms protein design—from structure prediction to function optimization—accelerating next-generation biotechnology.
🔗 onlinelibrary.wiley.com/d….
onlinelibrary.wiley.com
Protein engineering in the deep learning era
Advances in deep learning have significantly aided protein engineering in addressing challenges in industrial production, healthcare, and environmental sustainability. This review frames frequently r...
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Cutting-edge microbial techniques you should know— #mLife Collection I!
🔥From AI-driven protein design to single-cell analysis, genome editing, and environmental monitoring, these mLife papers are redefining how we study and engineer microbes.
11 highlights below ⬇️
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mist: MIST protein interaction database (2020).
The Molecular Interaction Search Tool (MIST) is a comprehensive resource of molecular interactions, assembled from severla primary sources.
7946 nodes, 250780 edges.
networks.skewed.de/net/mi…
Ridiculogram:
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Pharmacological Rescue of Follicle-Stimulating Hormone Receptor Mutants. In vitro and In silico Studies☨ pubmed.ncbi.nlm.nih.gov/4… #cryoEM
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@yanyuzhu.bsky.social
about 15 hours ago(3/6) The 'How-To' Guide. We provide a practical checklist for designing an imaging experiment, covering critical factors such as SNR vs SBR, optimizing probe design & delivery, spatial–temporal resolution, and microscope choices. #LiveCellImaging #Microscopy #SNR #Resolution #Biophysics
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Structural insights into inhibition mechanism of the helicase-primase complex from human herpesvirus 1 pubmed.ncbi.nlm.nih.gov/4… #cryoEM
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when I reflect on it, I think what got me into 'digesting images' directly from the screen was the rather trivial fact that I can zoom in/out into images (gels, westerns, SEM, TEM & cryoET micrographs) much like on an transilluminator. made me feel like in the lab 🤭
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Wow!!
Molecular dissection of protein complexes isolated from sections of human brain www.biorxiv.org/content/1….
Also complimentary:
www.biorxiv.org/content/1….
www.biorxiv.org
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@eu-science.bsky.social
about 16 hours agoBringing AI-driven protein-design tools to biologists everywhere | MIT News
www.europesays.com/uk/901259/
Artificial intelligence is already proving it can accelerate drug development and improve our understanding of disease. But to…
www.europesays.com
Bringing AI-driven protein-design tools to biologists everywhere | MIT News - United Kingdom
Artificial intelligence is already proving it can accelerate drug development and improve our understanding of disease. But to turn AI into novel treatments
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Researcher in Kalodimos Lab (incl NMR, cryo-EM) St. Jude Children's Research Hospital, Memphis, Tennessee, the Blue Sky Initiative “Seeing the Invisible in Protein Kinases” talent.stjude.org/careers…. #NMRjobs 🧲
talent.stjude.org
Researcher in Kalodimos Lab
Located at St. Jude Children's Research Hospital in Memphis, Tennesee, this position is part of the Blue Sky Initiative “Seeing the Invisible in Protein Kinases,” an inter-disciplinary and...
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@uk-news.bsky.social
about 17 hours agoBringing AI-driven protein-design tools to biologists everywhere | MIT News
www.europesays.com/uk/901259/
Artificial intelligence is already proving it can accelerate drug development and improve our understanding of disease. But to…#uk #news #uknews
www.europesays.com
Bringing AI-driven protein-design tools to biologists everywhere | MIT News - United Kingdom
Artificial intelligence is already proving it can accelerate drug development and improve our understanding of disease. But to turn AI into novel treatments
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Super cool! Could we do this with a pro-inflammatory bias to boost immune response against cancer in the lung?
Also thinking if it could be a good vehicle for engineered cytokines like the Baker lab’s neoleukins…
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