Suleman Bhana, MD 
biyouhifuko.com
オンライン診療で処方トラブルが増加、メール診療は違法の可能性 「ダイエット」「美容」目的の薬のオンライン処方、東京都が注意のポイントを提示
オンライン診療の普及が進む一方で、診察不足のまま薬が処方されたり、高額な定期購入が行われたりするなどのトラブル相談が増えている。
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Kenya’s health workforce must catch up with the rising tide of cardiometabolic diseases.
Our new issue briefly outlines how stronger training, updated curriculum, and better infrastructure can equip health professionals to deliver quality CMD care.
🔗 buff.ly/NCfrt44
#APHRCResearch #IamAPHRC
buff.ly
Strengthening Capacity of Health Professionals to Address Kenya’s Rising Burden of Cardiometabolic Diseases - APHRC
Executive Summary Limited faculty capacity, outdated curricula, inadequate research infrastructure, and weak knowledge translation mechanisms are undermining the ability of [...]Read More...
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Cardiometabolic health and physical robustness map onto distinct patterns of #brain structure and neurotransmitter systems @PLOSBiology.org
dlvr.it
Cardiometabolic health and physical robustness map onto distinct patterns of #brain structure and neurotransmitter systems
by Eliana Nicolaisen-Sobesky, Somayeh Maleki Balajoo, Mostafa Mahdipour, Agoston Mihalik, Mahnaz Olfati, Felix Hoffstaedter, Janaina Mourão-Miranda, Masoud Tahmasian, Simon B. Eickhoff, Sarah Genon The link between brain health and risk/protective factors for non-communicable diseases (such as high blood pressure, high body mass index, diet, smoking, physical activity, etc.) is increasingly acknowledged. However, the specific effects that these factors have on brain health are still poorly understood, delaying their implementation in precision brain health. Here, we studied the multivariate relationships between risk factors for non-communicable diseases and brain structure, including cortical thickness (CT) and gray matter volume (GMV). Furthermore, we adopted a systems-level perspective to understand such relationships, by characterizing the cortical patterns (yielded in association to risk factors) with regards to brain morphological and functional features, as well as with neurotransmitter systems. Similarly, we related the pattern of risk/protective factors dimensions with a peripheral marker of inflammation. First, we identified latent dimensions linking a broad set of risk factors for non-communicable diseases to parcel-wise CT and GMV across the whole cortex. Data was obtained from the UK Biobank (n = 7,370, age range = 46–81 years). We used regularized canonical correlation analysis (RCCA) embedded in a machine learning framework. This approach allows us to capture inter-individual variability in a multivariate association and to assess the generalizability of the model. The brain patterns (captured in association with risk/protective factors) were characterized from a multi-level perspective, by performing correlations (spin tests) between them and different brain patterns of structure, function, and neurotransmitter systems. The association between the risk/protective factors pattern and C-reactive protein (CRP, a marker of inflammation) was examined using Spearman correlation. We found two significant and partly replicable latent dimensions. One latent dimension linked cardiometabolic health to brain patterns of CT and GMV and was consistent across sexes. The other latent dimension linked physical robustness (including non-fat mass and strength) to patterns of CT and GMV, with the association to GMV being consistent across sexes and the association to CT appearing only in men. The CT and GMV patterns of both latent dimensions were associated to the binding potentials of several neurotransmitter systems. Finally, the cardiometabolic health dimension was correlated to CRP, while physical robustness was only very weakly associated to it. We observed robust, multi-level and multivariate links between both cardiometabolic health and physical robustness with respect to CT, GMV, and neurotransmitter systems. Interestingly, we found that cardiometabolic health and physical robustness are associated with not only increases in CT or GMV, but also with decreases of CT or GMV in some brain regions. Our results also suggested a role for low-grade chronic inflammation in the association between cardiometabolic health and brain structural health. These findings support the relevance of adopting a holistic perspective in health, by integrating neurocognitive and physical health. Moreover, our findings contribute to the challenge to the classical conceptualization of neuropsychiatric and physical illnesses as categorical entities. In this perspective, future studies should further examine the effects of risk/protective factors on different brain regions in order to deepen our understanding of the clinical significance of such increased and decreased CT and GMV.
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Breakfast: Protein shake + protein bar.
No lunch. No snacks. No coffee w/ creamer anymore.
One Monster Zero Ultra.
Dinner: a handful of cherries + a handful of grapes.
Maybe a cheese stick later.
No hunger or cravings.
This is a normal day.
#GLP1
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GLP1 Therapy and Metabolic Pathway Repair After Twelve Months
open.substack.com/pub/jus….
open.substack.com
GLP1 Therapy and Metabolic Pathway Repair After Twelve Months
How long term GLP1 treatment may help restore disrupted cellular metabolism in people with insulin resistance
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Not medical advice. As you increase the dose the hunger should get better. (At higher doses some people experience more nausea with wegovy at the same glp1 dose).
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I’ve been prediabetic basically my whole adult life and had to start taking tirzepatide (a glp1 & GIP drug) to manage insulin resistance & the side effects are kicking in & Jfc people willingly do this?!?
Ironically we’re hoping this gets me to eat more not less because my IR causes severe nausea
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IMO the rise of fascism and the return of heroin chic skinny are absolutely linked. I feel like it's why GLP1 drugs have been glamorized by celebrities and pumped out by drs to people at perfectly normal body weights.
They like their women weak.
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Great article by @fperrywilson.bsky.social about how GLP-1 treatments are a pharmaceutical goldmine: "For most people, stopping the GLP-1s means an eventual return to their baseline state." You'll gain that weight back when you stop treatment. #GLP1 #obesity
www.medscape.com/viewarti….
www.medscape.com
What Comes Back When Stopping GLP-1s?
We knew the weight would return, but what happens to the other benefits when patients are no longer taking GLP-1 drugs?
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For tea drinkers, cardiometabolic risk decreased the most for those who drank up to three cups daily, but the benefits tapered off after that.
www.nbcnews.com
Drinking this much coffee a day is linked to a lower risk of several diseases
People who consumed 200 to 300 milligrams of caffeine a day were less likely to develop coronary heart disease, Type 2 diabetes or stroke.
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Coffee drinkers, in particular, had the lowest risk — a nearly 50% reduction — while people who got the 200 to 300 milligrams of caffeine from tea or a mix of both beverages were about 40% less likely to develop cardiometabolic disease.
www.nbcnews.com
Drinking this much coffee a day is linked to a lower risk of several diseases
People who consumed 200 to 300 milligrams of caffeine a day were less likely to develop coronary heart disease, Type 2 diabetes or stroke.
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Drinking two to three cups of coffee or up to three cups of tea a day was the sweet spot, the researchers found.
People who consumed about 200 to 300 milligrams of caffeine daily had a lower risk of cardiometabolic disease, compared to people who drank less than 100 mg a day.
www.nbcnews.com
Drinking this much coffee a day is linked to a lower risk of several diseases
People who consumed 200 to 300 milligrams of caffeine a day were less likely to develop coronary heart disease, Type 2 diabetes or stroke.
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They overstate the amount of R&D they do, and how much it costs.
For example, Insulin was isolated by Banting and Best in 1921 and US pharma still charges obscene amounts for it. More recently, the GLP1 receptor agonists (ie weight-loss drugs) were mostly developed through the NIH, not commercially
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Position Statement on Cardiometabolic Health Across the Woman's Life Course - 2025 pubmed.ncbi.nlm.nih.gov/4…
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💥 Korea’s first GLP-1 obesity drug is racing to market! 💊
Hanmi’s Efpeglenatide just got fast-tracked for approval — marking a turning point in Korean biotech innovation.
🔗 Full story: koreatechdesk.com/koreas-….
#HanmiPharma #GLP1 #Biotech #KoreanInnovation #KoreaTechDesk
koreatechdesk.com
Korea’s First GLP-1 Obesity Drug Fast-Tracked: Hanmi’s “Efpeglenatide” Signals Acceleration in Biotech Commercialization - KoreaTechDesk | Korean Startup and Technology News
Hanmi’s Efpeglenatide earns fast-track review in Korea, marking a breakthrough in biotech commercialization and homegrown GLP-1 drug innovation.
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So I paid for this. Dearly. Awake for hours with fiery acid reflux. I did not take my own advice. DO NOT EAT SWEETS WHILE ON #GLP1! It will come back to bite you, literally.
𝕖𝕔𝕜𝕤𝕥𝕖𝕚𝕟@ecksteinish.bsky.social
I was bad. I bought a Buttermilk Chess Pie. They are hard to find around here so I couldn't resist.
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#WeekendRead! #FriendOrFoe? Yu, Lozinski, Dong, &co show @natneuro.nature.com that host-derived oxidized lipid deposition in the brain supports multiple sclerosis development via microglia dysfunction/replacement by monocyte-derived macrophages & interleukin-1 #IL1 signaling! doi.org/10.1038/s415...
doi.org
Oxidized phosphatidylcholines deposition drives chronic neurodegeneration in a mouse model of progressive multiple sclerosis via IL-1β signaling - Nature Neuroscience
In this study, Yu et al. found that a positive feedback loop between oxidized phosphatidylcholine and IL-1β promotes chronic neurodegeneration in the central nervous system and could be a contributing...
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Once we're all addicted to GLP1 drugs we'll have finally solved addiction 🤔
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"#Throwback 🧪
COMMENT | Shaping the future of cardiometabolic innovation: advances and opportunities
@clemmensenc.bsky.social et al
bit.ly/4iIBBvY
bit.ly
Shaping the future of cardiometabolic innovation: advances and opportunities - Nature Metabolism
Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides our views on recent breakthroughs, emerging innovations and future needs of therapeutic interventions to counteract obesity and its associated health risks.
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Oxidized low-density lipoprotein cholesterol and plaque vulnerability🔓
www.sciencedirect.com/sci….
www.sciencedirect.com
Oxidized low-density lipoprotein cholesterol and plaque vulnerability
The oxidation of low-density lipoprotein cholesterol (LDL-C) plays a critical role in plaque inflammation and the subsequent high-risk plaque formatio…
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Effects of maternal and paternal smoking on offspring cardiometabolic risk factors in adulthood: a multi-method intergenerational Mendelian randomization study www.medrxiv.org/content/1…
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UW Medicine's Dr. Scott Hagan talks about the pros and cons of the GLP-1s. As costs go down, what should you talk about with your doctor? #ozempic #glp1 #diet #weightloss.https://bit.ly/4iCS5Wa
bit.ly
Ask a Doctor: Ozempic, Wegovy and GLP-1 drugs in general
GLP-1 drugs like, Ozempic and Wegovy, are in big demand... And they’re going to be more affordable. Two physicians answer the questions we still have about GLP-1s.
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