Alex Rubinsteyn www.the-scientist.com
Immune Markers Help Identify Subgroups of ME/CFS Patients
Proteins involved in neuroinflammation found in the cerebrospinal fluid could help researchers better diagnose and treat chronic fatigue syndrome.
Feed for immunology research. Tag posts with ⑂, #immunosky, or immunology jargon like #lymphocyte.
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🧩 Antigen presentation is complex - but imaging is bringing clarity.
@doreenlau.bsky.social & @timmunologist.bsky.social review how advanced imaging illuminates T-cell–APC interactions, peptide-MHC dynamics, and more in cancer immunity.
📖 bit.ly/3TkIasN
#CancerImmunology
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A ‘simple’ experiment but an amazing gem of a reference!
Just stimulate blood, observe and describe…
#ImmunoSky
Adam Braithwaite@braithwaiteat.bsky.social
Stimulating immune cells in vitro is a common experimental lab model. We profiled 150K blood immune cells treated with 11 different stimuli to compare the effects. The data are freely available for researchers. See the preprint for our findings and to access the data 🧪 doi.org/10.1101/2025...
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🧬 CD28 vs. TCR: not a one-size-fits-all signal.
New study by Cayman Williams et al. shows CD28 co-stimulation shapes naïve & memory CD4⁺ T cells differently - and can even act independently of TCR in memory cells.
📖 bit.ly/44MG7UD
#Tcells #Immunology
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We compared the single cell transcriptome profiles of 150K immune cells treated with 11 different simulations to multiple inflammatory disease profiles. This open resource can help in selecting more disease-relevant in vitro conditions for immune cells. doi.org/10.1101/2025...
🧪🧬🖥️ #immunosky #medsky
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#Medsky🧪 #cardiosky #pedsky #immunosky #pharmasky Among pediatric patients with #intracardiacthrombosis , irrespective of the thrombosis site, rivaroxaban seemed effective in thrombus resolution.
www.sciencedirect.com/sci….
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#medsky🧪 #IDsky #immunosky #publichealth @virusesimmunity.bsky.social et al Proteins involved in neuroinflammation found in the cerebrospinal fluid could help researchers better diagnose and treat ME/CSF
www.the-scientist.com/profiling-im...
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@jyves94.bsky.social
29 days agoLa #FDA des #USA accorde une #FastTrack 🚀 au #Linvoseltamab 💊, un engageur #Bispécifique des lymphocytes T #CD3 dirigé vers #BCMA, pour le #MyélomeMultiple 🩸 R/R, qui ont reçu ≥4 LOT auparavant, y compris un IP, un #IMiD et un #AnticorpsMonoclonal anti- #CD38
www.fda.gov/drugs/resour...
www.fda.gov
FDA grants accelerated approval to linvoseltamab-gcpt for relapsed or
FDA grants accelerated approval to linvoseltamab-gcpt for relapsed or refractory multiple myeloma
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Our latest review: Inborn errors of immunity affecting the MHC class I pathway for antigen presentation url: rupress.org/jhi/article/...
rupress.org
Inborn errors of immunity affecting the MHC class I pathway for antigen presentation | Journal of Human Immunity | Rockefeller University Press
The paper discusses rare inborn errors of immunity affecting MHC class I antigen processing, leading to infections and skin lesions, often misdiagnosed as
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As paper titles involving TB go, this one using the rhyming Fc is not bad...
(also a good synopsis of an important paper)
#IDSky #TBSky #immunosky
www.science.org/doi/10.11….
www.science.org
TB or not TB: That depends on the antibody Fc
Fc-swapped variant monoclonal antibodies reveal new mechanisms underlying Mycobacterium tuberculosis restriction.
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Microglial cGAS-STING-TBK1 activation in paraventricular thalamus mediates sleep and emotional disturbances in lupus mice www.sciencedirect.com/sci….
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#Medsky🧪 #Immunosky #neurosky In this review, the study discuss the #lipidmetabolism & #immuneresponse in AD, summarize their intricate interactions & highlight the complexity of the multifactorial pathogenic cascade …
BMC@bmc.springernature.com
A Review published in Molecular Neurodegeneration discusses the lipid metabolism and immune response in Alzheimer’s disease, summarizing their intricate interactions and offering insights into new interventions targeting the immune-metabolic axis in AD. #MedSky
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Join us for an informative DRESS Syndrome Webinar!
Leading experts, patients, and loved ones share insights & stories.
📅 National DRESS Syndrome Day — July 16, 2025 (12–2 PM ET)
🔗 Register & learn more: bit.ly/FacesOfDRESS
#DRESSsyndrome #drugallergy #dermsky #medsky #Immunosky #allergysky #IDsky
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Brilliant talk by Lance from our lab at the 2nd ASPIRE Meeting about his soon to be online study on understanding microglia subsets in AD and what we can learn about windows of opportunity to modulate them!
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We are hiring. Join us if you like the topic. Also, we’re nice and dedicated people here @immunosens.bsky.social @unibonn.bsky.social 🥸 Exiting times ahead in #immunosky & #retroelements
Funded by @erc.europa.eu
www.nature.com/naturecareer...
www.nature.com
Postdoctoral fellow (m/w/d) – Sterile Inflammation & Epigenetics - Bonn, Nordrhein-Westfalen (DE) job with Universitätsklinikum Bonn | 12841086
The University Hospital Bonn (UKB) is a maximum care hospital with more than 1,300 beds. Our more than 9,000 employees take on tasks in research, t...
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#Medsky🧪 #IDSky #pedsky #Immunosky #publichealth Infections with #SARSCoV2 can lead to a range of clinical manifestations . In the current lack of corroborating published evidences, raise questions about the relevance of IL1RA as an autoantibody target in COVID related clinical manifestations & AEFI
Petter Brodin@petterbrodin.bsky.social
No evidence for neutralizing IL1RN autoantibodies in our cohorts of MIS-C, SARS-CoV2 pneumonia or vaccine-induced myocarditis. onlinelibrary.wiley.com/doi/10.1111/... Great work by Anish Behere in Nils Landegren lab, Uppsala university
onlinelibrary.wiley.com
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ME/CFS disability varies wildly because T cell exhaustion isn’t one-size-fits-all. It’s a spectrum, from mild battery drain to total shutdown, impacting energy, immunity & symptoms. 🔬💥 #MECFS #Immunology #ChronicFatigue
Read more: medium.com/@w.gielen/th...
medium.com
The Exhaustion Enigma: Why ME/CFS Disability Varies Wildly Despite T Cell Exhaustion
If you or a loved one lives with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), you’ve witnessed the cruel paradox: one…
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ME/CFS & Long COVID are tough to treat, but new research reveals T-cell exhaustion as a key culprit. Low-dose naltrexone (LDN) shows promise in restoring immune balance & easing symptoms.🌟
👉 medium.com/@w.gielen/ho...
#ChronicIllness #ImmuneHealth #LDN #PostViralSyndromes #Innovation
medium.com
How LDN Targets T-Cell Exhaustion in ME/CFS
For decades, ME/CFS has been a medical mystery; its sufferers have been dismissed, its symptoms misunderstood, and its cause has been…
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#Medsky🧪 #IDsky #immunosky #episky #pedsky #publichealth . Regardless the anti- #science www.npr.org/sections/goa... & the recent “kill bill” from the current 🇺🇸 gov . Remembered this “ #Vaccines saved life”
ourworldindata.org/vaccin….
ourworldindata.org
Vaccines have saved 150 million children over the last 50 years
Every ten seconds, one child is saved by a vaccine against a fatal disease.
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“The [RFKJr appointed] panel’s overall lack of knowledge showed. CDC scientists and [Pediatrician Cody] Meissner repeatedly had to correct or instruct the panelists on procedures, basic immunology and even how clinical trials work.”
#VaccinePolicy
#Immunology
#PublicHealth
#ACIP #CDC
#RFKJr 👇🏼
Ian Weissman, DO@drianweissman.bsky.social
Vaccine policy in the U.S. is entering uncharted territory. A key vaccine advisory group vows to base decisions on evidence, boost confidence in vaccines and protect health. Experts fear the opposite is happening. www.sciencenews.Vaccineorg/article/vacc...
www.sciencenews.org
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#Medsky🧪 #IDsky #immunosky #publichealth At the end of the day #SARCoV2 is still the most sophisticated & deadly 🦠 of the above with it’s nucleocapsid protein abilities to recombine & annealing host RNA for its viral replication & mutations purposes
www.sciencedirect.com/sci….
www.sciencedirect.com
Chaperone Activity of SARS-CoV-2 Nucleocapsid Protein: RNA Annealing and Destabilization Mechanisms
The recent global COVID-19 pandemic has prompted new research in coronaviruses. Despite the discovery of effective vaccines and therapeutic interventi…
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#SustainableDevelopmentGoals #SDGs #ecotoxicology #ecology #publichealth #hepatology #oncology #sustainability #menopause #geriatrics #gerontology #pathology #dementia #Alzheimers #toxicology #immunology #endocrinology #NCDs
74% higher
liver cadmium
in women
.
www.tandfonline.com/doi/a….
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In #Science #Immunology, @tobiasplowman.bsky.social, Kassiotis, & al report canonical #IL13RA1 expression is negatively regulated by E2 #estrogen & also describe a primate-specific RTE-derived IL-13Rα1 isoform that antagonizes the canonical receptor & attenuates responsiveness to #IL4 and #IL13!
www.science.org
Primate retroelement exonization and sexually dimorphic IL13RA1 transcription tune type 2 immune responses
Co-option of primate-specific retroelements creates an alternative IL-13Rα1 subunit that tunes type 2 immune responses.
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