CRISPR

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Cell-specific DNA methylation in human alpha and beta cells regulates gene expression in type 2 diabetes

Nature Metabolism, Published online: 24 April 2026; doi:10.1038/s42255-026-01498-9Mapping of genome-wide DNA methylation patterns in human islet alpha and beta cells highlights age- and type 2 diabetes-dependent adaptations, and CRISPR-based epigenetic editing strategies validate key targets in human islet beta cells.

www.dementiaresearcher.nihr.ac.uk

Research Assistant: Function-resolved biology of ATM

Research Assistant at Cambridge studying ATM DNA damage biology using CRISPR and cell models to identify therapies for rare disease and cancer.

cnb.cx

Intellia Therapeutics says its Crispr-based treatment succeeds in pivotal trial

Intellia Therapeutics said its Crispr-based treatment for hereditary angioedema met its goals in a Phase 3 trial, marking a milestone for gene editing.

doi.org

Essentiality and dynamic expression of the human tRNA pool during viral infection - Molecular Systems Biology

Human viruses rely on host translation resources, including the cellular tRNA pool, because they lack tRNA genes. Using tRNA sequencing, we profiled mature tRNAs during infections with human cytomegalovirus (HCMV) and SARS-CoV-2. HCMV-induced alterations in mature tRNA levels were predominantly virus-driven, with minimal influence from the cellular immune response. Certain post-transcriptional modifications, correlated with tRNA stability, were actively manipulated by HCMV. By contrast, SARS-CoV-2 caused minimal changes in mature tRNA levels or modifications. Comparing viral codon usage with proliferation- versus differentiation-associated codon-usage signatures in human genes revealed striking divergence. HCMV genes aligned with differentiation codon usage, whereas SARS-CoV-2 genes matched proliferation codon usage. Structural and gene-expression genes in both viruses showed strong adaptation to host tRNA pools. Finally, a systematic CRISPR screen of human tRNA genes and tRNA-modifying enzymes identified specific tRNAs and enzymes that either enhanced or restricted HCMV infectivity and influenced cellular growth. Together, these data define a dynamic interplay between the host tRNA landscape and viral infection, illuminating the mechanisms governing host–virus interactions.

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dlvr.it

Cell-specific DNA methylation in human alpha and beta cells regulates gene expression in type 2 diabetes

Nature Metabolism, Published online: 24 April 2026; doi:10.1038/s42255-026-01498-9Mapping of genome-wide DNA methylation patterns in human islet alpha and beta cells highlights age- and type 2 diabetes-dependent adaptations, and CRISPR-based epigenetic editing strategies validate key targets in human islet beta cells.

www.genengnews.com

CRISPR Screens Map Human T‑Cell Genes That Promote or Block HIV Infection

Genome‑wide CRISPR screens in primary human T cells reveal human genes that promote or block HIV infection, uncovering potent antiviral factors like PI16 and PPID.

dlvr.it

Genome-Wide CRISPR Knockout Screening Identifies Novel Disease-Associated Genes in Retinal Pigment Epithelium Cells

Publication date: Available online 19 April 2026 Source: Experimental Eye Research Author(s): Rui Li, Lei Xie, Jing Hu, Bei Liu, Haijiang Zhang, Hao Qian

www.reuters.com

Researchers eye potential Down syndrome fix via advanced gene editing

Researchers have developed a modified version of the CRISPR gene-editing tool that in early laboratory experiments suggests it may have the potential to “silence” ​the extra chromosome that causes Dow...

f.mtr.cool

The Push for Artificial Inheritance

Experts worry about the risks of editing genes in human embryos. New startups seem poised to throw caution to the wind.

www.aamc.org

4 medical breakthroughs that are transforming patient care

From minimally invasive heart bypass surgery to personalized CRISPR gene editing therapy, these medical “firsts” are improving and saving patients’ lives.

www.nytimes.com

oncodaily.com

Yan Leyfman: Gene Editing Rapidly Redefines What is Possible in Sickle Cell Disease - OncoDaily

Yan Leyfman: Gene Editing Rapidly Redefines What is Possible in Sickle Cell Disease / Akshay Sharma, Baisong Mei, cancer, Christopher McKinney, CRISPR-Cas12a,

www.theguardian.com

Scientists develop gene-edited wheat that can make toasted bread less carcinogenic

Bread and biscuits made from Crispr-edited wheat showed substantially reduced acrylamide levels, even after toasting Gene-edited wheat which can make bread less carcinogenic when toasted has been successfully developed by scientists. Researchers at Rothamsted Research in Harpenden, Hertfordshire, used Crispr genome editing which allows researchers to selectively edit the DNA of living organisms. This revolutionary technology was adapted for use in the laboratory from naturally occurring genome editing systems found in bacteria. Continue reading...