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ViroSky

ViroSky

byRhys ParryRhys Parry

A collection of #virology and posts from virologists making the move to Bluesky Social. Flag @rhyshparry.bsky.social to be added. //Made at BlueskyFeeds.com

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  • 💙 Liked by 81users
  • 📅 Updated almost 3 years ago
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Jasnah Kholin
@jasnah.bsky.social
about 3 hours ago
hard to say conclusively, can't find any Cyclospora-specific studies; the somewhat closely related Cryptosporidium *can* be UVC-inactivated (pmc.ncbi.nlm.nih.gov/arti…) but the dose needed is quite high & that's in water, not something w/opacity like lettuce. not sure i'd chance it, tbh.
Efficacy of UV Irradiation in Inactivating Cryptosporidium parvum Oocysts

pmc.ncbi.nlm.nih.gov

Efficacy of UV Irradiation in Inactivating Cryptosporidium parvum Oocysts

To evaluate the effectiveness of UV irradiation in inactivating Cryptosporidium parvum oocysts, the animal infectivities and excystation abilities of oocysts that had been exposed to various UV doses ...

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Cadhla Firth
@cadhlafirth.bsky.social
about 8 hours ago
Seems like they did a fine job helping identify Taylor Farms to me 🤷‍♀️
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Cadhla Firth
@cadhlafirth.bsky.social
about 8 hours ago
The CDC isn't used to dealing with outbreaks???
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Jason Rasgon
@vectorgen.bsky.social
about 9 hours ago
Benedict Townsend: No We Don't

static.klipy.com

Benedict Townsend: No We Don't

ALT: Benedict Townsend: No We Don't

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Ryan Hisner
@ryanhisner.bsky.social
about 10 hours ago
To either use real HEPA filters or else use non-HEPA and be upfront about it. And don't use ionizers, or at least be clear about it if you do. Pretty simple.
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Jason Rasgon
@vectorgen.bsky.social
about 11 hours ago
bsky.app/profile/vect...

Update. Although the ingredients list "apples" the bag does, indeed, contain strawberries

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Jason Rasgon
@vectorgen.bsky.social
about 11 hours ago
Update. Although the ingredients list "apples" the bag does, indeed, contain strawberries

This is enraging

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Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀
@edrybicki.bsky.social
about 11 hours ago
TRANSPOSOOOOOONS!!
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Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀
@edrybicki.bsky.social
about 11 hours ago
Likewise - although mine are succumbing to wooolly bear and some black fungus and rats…long skinny VICIOUSLY hot ones, short fat hottish, and big, round so-called peppadews. A natural hybrid of pepper and chillie, apparently, and REALLY nice. Pickle well, too.
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Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀
@edrybicki.bsky.social
about 11 hours ago
Always a good thing! I have a basket full of dried chillies, and a jar or two of processed. That would make smoke come out of your ears…
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Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀
@edrybicki.bsky.social
about 11 hours ago
Always useful to have a dead person whose teachings you can “interpret”.
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Jason Rasgon
@vectorgen.bsky.social
about 12 hours ago
345 in State College
Patrick Star's Hilarious Coughing Fit

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Patrick Star's Hilarious Coughing Fit

ALT: Patrick Star's Hilarious Coughing Fit

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Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀
@edrybicki.bsky.social
about 14 hours ago
Ah, Saul of Tarsus! The tax collector who had visions after walking into a wagon on the road to Damascus. Who had never met said Yeshua, but knew a good bandwagon when he saw one.
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Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀
@edrybicki.bsky.social
about 14 hours ago
Because Yeshua bar Yusuf did not exist. Or if he did, was nothing like what has has been written about him. LONG after his purported death, in a time where scribes were recording events of note.
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Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀
@edrybicki.bsky.social
about 14 hours ago
And apropos of fiction, that Morgan fellow has some good stuff out…?
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Alex Crits-Christoph
@acritschristoph.bsky.social
about 14 hours ago
I currently have isolate genomes in limbo for >8 months 😭
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Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀
@edrybicki.bsky.social
about 14 hours ago
Laughing Laughing Hysterically

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Laughing Laughing Hysterically

ALT: Laughing Laughing Hysterically

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Ryan Hisner
@ryanhisner.bsky.social
about 15 hours ago
It's a sick, sick country. www.haaretz.com/israel-ne….
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Ryan Hisner
@ryanhisner.bsky.social
about 16 hours ago
ORF6 is a SARS-2 protein that shuts down traffic between the nucleus & cytoplasm in host cells, inhibiting host mRNA export & immune responses. But in all variants since early 2023, ORF6's abilities are hampered by the ORF6:D61L mutation. Two newish ORF6 observations.... 1/15
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Ryan Hisner
@ryanhisner.bsky.social
about 16 hours ago
First, BA.3.2—saltation variant from ~3-year chronic infection—is the first variant since BA.5 to lack ORF6:D61L. Instead, it gets D61H + an LNEQT extension. This has been entirely overlooked, including by me. Does this restore ORF6's powers—or further cripple them? 2/15
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Ryan Hisner
@ryanhisner.bsky.social
about 16 hours ago
ORF6's tail is key for binding to the nuclear pore & shutting it down. Negative charge (D's & E's) is crucial for this, which is why loss of the C-terminal D inhibits its function. BA.3.2 lacks D61 but adds an E three sites down. Might this restore ORF6's powers? Or does it further inhibit it? 3/15
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Ryan Hisner
@ryanhisner.bsky.social
about 16 hours ago
All of the ORF6:52-61 residues are highly conserved in sarbecoviruses, with the exception of Q56. Mutation experiments suggest M58 is crucial & that more negative charge = higher binding to the nuclear pore complex (NPC). 4/15
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Ryan Hisner
@ryanhisner.bsky.social
about 16 hours ago
Some sarbecos (e.g. SARS-1) have a 2-AA extension on ORF6. Removing the extension from SARS-1 enormously increases its NPC binding, but adding it to SARS-2 ORF6 slight increases its binding. So we know C-terminal extensions can have a large effect, but in complex, hard-to-predict ways. 5/15
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