Open Access (en)

doi.org

Climatic gradients associated with heat stress predict shell geometry in rock-dwelling land snails

Abstract Shell morphology in terrestrial gastropods is widely assumed to reflect climatic adaptation, yet empirical support for body size-climate relationships remains inconsistent across scales. We i...

intellectdiscover.com

Platform journalism on YouTube: A democratic functions approach to analysing journalism on digital platforms | Intellect

Independent youtubers who create content on political, social and economic issues attract very large audiences and are increasingly the object of study for journalism scholars. This article contribute...

jpsyexp.org

Why Publish with Us

Discover the benefits of publishing with Journal of Psychological Experience, including rapid publication, multilingual abstracts, and global reach.

ojs.wgtn.ac.nz

A Strong and Resilient Research System is Built by Valuing People | New Zealand Science Review

sparcopen.org

Power, Equity, and the Future of Open - SPARC

Building on our popular “Open Access 101” events, SPARC is pleased to announce a new series, Collections & Open Access: Resourcing Open Scholarship, that will dive deeper into topics at the intersecti...

doi.org

Historia naturalis bulgarica | Medicinal plant database of the Republic of Buryatia (Russia)

Historia naturalis bulgarica -- Volume 48 (2026) -- Medicinal plant database of the Republic of Buryatia (Russia) -- Article synopsis

doi.org

Historia naturalis bulgarica | Studies on the Balkan Lepidoptera II. Expected and unexpected species in Albania, September 2025

Historia naturalis bulgarica -- Volume 48 (2026) -- Studies on the Balkan Lepidoptera II. Expected and unexpected species in Albania, September 2025 -- Article synopsis

doi.org

Historia naturalis bulgarica | The rediscovery of Isolabella graeca Verhoeff, 1902 (Dermaptera, Spongiphoridae) in Greece after 123 years

Historia naturalis bulgarica -- Volume 48 (2026) -- The rediscovery of Isolabella graeca Verhoeff, 1902 (Dermaptera, Spongiphoridae) in Greece after 123 years -- Article synopsis

arxiv.org

Estimating global article processing charges paid to 14 publishers for open access between 2019 and 2025

This study presents estimates of the global expenditure on article processing charges (APCs) paid to 14 publishers for open access (OA) between 2019 and 2025. APCs are charged for publishing in fully ...

doi.org

Protective actions of phosphoinositide 3-kinase (p110α) in a setting of cardiomyopathy

Heart failure affects approximately 1-3% of Western society. There is currently no cure and treatments largely delay disease progression. Consequently, there is great interest in identifying strategies that can improve cardiac function and reverse some of the negative consequences associated with heart failure. This thesis investigates the cardioprotective properties of a gene activated in the athlete’s heart [phosphoinositide 3-kinase (PI3K), p110α] in a setting of heart failure. Two double-transgenic mouse models were generated to assess the role of PI3K in a setting of cardiac stress (dilated cardiomyopathy, DCM). Mice either expressing a constitutively active mutant of PI3K (p110α) (caPI3K) or a dominant negative mutant of PI3K (p110α) (dnPI3K) were crossed with a transgenic mouse model of DCM [due to over-expression of mammalian sterile 20-like kinase 1 (Mst1)]. Increasing PI3K activity in the DCM model (caPI3K-Mst1) improved lifespan and cardiac function, whereas decreasing PI3K activity in the DCM model (dnPI3K-Mst1) had an adverse effect. The cardioprotective properties of PI3K (p110α) were mediated, at least in part, by the kinase Akt. Using the dnPI3K-Mst1 model, I was able to show that reduced PI3K (p110α) activity increases the heart’s susceptibility to atrial fibrillation (AF, the most common arrhythmia in cardiology departments worldwide). dnPI3K-Mst1 mice displayed overt atrial remodelling, varying degrees of conduction blockade and developed spontaneous AF. To assess a possible link between PI3K activity and AF in humans, PI3K (p110α) activity was measured in atrial appendages of patients with AF (acute or chronic) and compared to patients without AF. PI3K (p110α) activity was lower in patients with AF compared to patients in sinus rhythm. These results suggest that reduced PI3K (p110α) makes the heart more susceptible to the development of AF. Thus, strategies or agents that can activate PI3K (p110α) specifically in the heart may represent a useful therapeutic approach for AF. An unanticipated but novel finding was the observation that female dnPI3K-Mst1 mice showed faster disease progression than males. Prior to menopause, females are normally protected against cardiovascular disease compared with males. In contrast, in settings of aging, diabetes or hypertension [associated with depressed or defective PI3K (p110α) activity] females are more prone to cardiac disease than males. Taken together with my results, this suggests that there may be an interaction between PI3K (p110α) and estrogen, and that this interaction is essential for the cardioprotection seen in pre-menopausal women. Data obtained from dnPI3K-Mst1 mice suggests that PI3K (p110α) plays an important role in mediating cardioprotection in females. Unexpectedly, ovariectomy had a beneficial effect on the cardiac phenotype of Mst1 mice, but no significant effect in caPI3K-Mst1 or dnPI3K-Mst1 mice. The mechanisms responsible for these phenotypes will require further investigation. In summary, this thesis presents compelling evidence to support investigation into therapeutics that activate components of the PI3K (p110α) signalling pathway in a setting of cardiac stress. Author requested conversion to open access 29 Oct 2022

doi.org

Demystifying Research Paradigms: Navigating Ontology, Epistemology, and Axiology in Research

A sound understanding of research paradigms is crucial for developing coherent and philosophically grounded research designs, particularly in the humanities and social sciences. This paper offers an a...

muse.jhu.edu

Project MUSE -- Verification required!

academic.oup.com

Do algorithmic information environments mark the end of media effects research?

Abstract. Algorithmically curated information environments are beginning to challenge both long-standing notions of what media effects look like and our ab

journals.sagepub.com

Sage Journals: Discover world-class research

Subscription and open access journals from Sage, the world's leading independent academic publisher.