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Steve Baker @bakersm11.bsky.social · 2 days ago
mixing 🧪🧬WT & H35L (dominant negative) protomeres can also inhibit hemolytic activity or DEPC Histidine crosslinking depending upon the ratio and some of the HLA peptides have interesting properties (e.g., pmc.ncbi.nlm.nih.gov/arti…)
The H35A Mutated Alpha-Toxin Interferes with Cytotoxicity of Staphylococcal Alpha-Toxin

pmc.ncbi.nlm.nih.gov

The H35A Mutated Alpha-Toxin Interferes with Cytotoxicity of Staphylococcal Alpha-Toxin

Staphylococcal alpha-toxin is an important virulence factor for Staphylococcus aureus to cause severe infections. In this study, we explored whether the toxoid of alpha-toxin may be utilized to block ...

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Steve Baker @bakersm11.bsky.social · 2 days ago
Thanks Dr. Todd, Nice to know the C15 (PA) fatty acid is saturated 🧪🧬and acts as a "statin" or HMG-CoA enzyme inhibitor affecting the mevalonate (isoprenoid) pathway but does PA also alter HMG-CoA reductase mediated (lipo)protein prenylation or ubiquitination/degradation of the enzyme itself ?
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